Mutation Status in Sinonasal Mucosal Melanoma
نویسندگان
چکیده
منابع مشابه
Sinonasal tract mucosal melanoma.
Mucosal melanoma is a neural-crest–derived neoplasm that originates in melanocytes and demonstrates melanocytic differentiation. Exposure to formalin and ultraviolet light are known etiologic factors; another possible factor is exposure to radiation. Approximately 15 to 20% of all skin melanomas develop on the head and neck, but less than 1% of all melanomas develop in ocular or mucosal sites, ...
متن کاملPTEN Methylation Dependent Sinonasal Mucosal Melanoma
Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism ...
متن کاملHigh-dose proton beam therapy for sinonasal mucosal malignant melanoma
BACKGROUND The significance of definitive radiotherapy for sinonasal mucosal melanoma (SMM) is sill controvertial. This study was to evaluate the role of high-dose proton beam therapy (PBT) in patients with SMM. METHODS The cases of 20 patients with SMM localized to the primary site who were treated by PBT between 2006 and 2012 were retrospectively analyzed. The patterns of overall survival a...
متن کاملNRAS and BRAF mutation frequency in primary oral mucosal melanoma.
Oral mucosal melanoma (OMM) is a fatal sarcoma of unknown etiology. Histological morphology and genetic events are distinct from those of its cutaneous counterpart. Mutation and up-regulation of c-kit has been identified in OMM which may activate downstream molecules such as RAS and RAF. These molecules are involved in the mitogen-activated protein kinase (MAPK) pathway leading to tremendous ce...
متن کاملMalignant Mucosal Melanoma of the Maxillary Sinus
Sinus mucosal malignant melanoma, is a rare type of melanoma with poor prognosis which is usually occurred in the adults. This is a rare case of a 33-year-old man presenting 2-week-long headache and nasal obstruction with the emphasis on the importance of Immunohistochemical staining to help the diagnosis.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurological Surgery Part B: Skull Base
سال: 2017
ISSN: 2193-6331,2193-634X
DOI: 10.1055/s-0037-1600615